The theory of endobiogeny: biological modeling using downstream physiologic output as inference of upstream global system regulation
Journal of Complexity in Health Sciences
Living organisms are physical, chemical and biological systems organized in fractal hierarchies of structure and function. Various levels of organization may be the object of study: cell, tissue, organ or whole system. The theory of endobiogeny is a global systems approach to living systems in which the patient as a whole is the object of study. It is a global living systems theory of terrain. The essential activity of the terrain is metabolism: the continuous transformation of energy and
... . According to this theory, the neuroendocrine system is the manager of metabolism and hence the terrain. Modeling the neuroendocrine elements of regulation of the terrain is a key tool in clinical assessment of patients. There are various limits to a strictly quantitative measurement of hormone levels and metabolic activity. Therefore, a modeling system has been developed which uses downstream biomarker output from tissues to assess upstream elements of management of the terrain. This method is called the Biology of Functions. Direct and indirect ratios of biomarkers and indexes have been developed to use quantized data to generate a qualitative analysis of relative capability of the organism. The construction of two direct indexes (genital ratio and genito-thyroid), and one indirect index (evoked histamine) are discussed.