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A role for Timeless in epithelial morphogenesis during kidney development
2000
Proceedings of the National Academy of Sciences of the United States of America
Central to the process of epithelial organogenesis is branching morphogenesis into tubules and ducts. In the kidney, this can be modeled by a very simple system consisting of isolated ureteric bud (UB) cells, which undergo branching morphogenesis in response to soluble factors present in the conditioned medium of a metanephric mesenchyme cell line. By employing a targeted screen to identify transcription factors involved early in the morphogenetic program leading to UB branching, we identified
doi:10.1073/pnas.97.18.10038
pmid:10963667
pmcid:PMC27664
fatcat:2jzwxzwuzndhlgjyjrytu54pnu