MOFzyme: Enzyme Mimics of Fe/Fe-MIL-101

Lingli Li, Daomei Chen, Bin Li, Dongqi Yang, Jingchen Zhao, Danhua Ma, Liang Jiang, Yepeng Yang, Yizhou Li, Jiaqiang Wang
2019 Journal of Biosciences and Medicines  
In this work, metal-organic frameworks (MOFs) Fe-MIL-101 was synthesized by hydrothermal method, and Fe/Fe-MIL-101 with different loadings was prepared. The crystal structure of the Fe/Fe-MIL-101 sample was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and specific surface area measurement (BET). Fe/Fe-MIL-101 was found to posses an intrinsic enzyme mimicking activity similar to that found in natural horseradish peroxidase (HRP). The Michaelis constant (K m ) of
more » ... Fe/Fe-MIL-101 with ABTS as the substrate is about 10-fold smaller than Fe-MIL-101 and about 3-fold smaller than HRP, and about 108 times less than that of CuO NPs (K m = 10.28 mM), indicating a much higher affinity for ABTS than HRP and most of the peroxidase mimetics.
doi:10.4236/jbm.2019.75023 fatcat:mpwb2iqsn5caxmcyys5mpkwb6u