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In pursuit to synthesize the molecules of biological interest we reported here the synthesis of some novel pyrazolines from piperazine chalcones under basic condition using hydrazine hydrate. Ethanol is used as a solvent medium for the reaction. These newly synthesized pyrazolines are screened for antimicrobial studies and showed moderate to good activity.doi:10.5281/zenodo.2349244 fatcat:qwkoustgqvcfdenaetqbmnspqm