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Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
2009
BMC Immunology
TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 are less prone to subsequent TCR-activation. The heterotrimeric G proteins G αq and G αi2 have been implicated in CXCR4-signaling and we have recently also reported the possible involvement of G αq in TCR-dependent activation of Lck (Ngai et al., Eur. J. Immunol., 2008, 38: 32083218). Here we examined the
doi:10.1186/1471-2172-10-27
pmid:19426503
pmcid:PMC2694176
fatcat:32y6udr2zbal7bppyxumw4rvqy