THU0004 Figure 3. 4. No effect on RAW264.7 macrophage apoptosis(Figure4) Abstract THU0004 Figure 4. 5. Effect of miR-223 on NLRP3 inflammasome expression in RAW264.7 macrophages treated with MSU(Figure5) Abstract THU0004 Figure 5. Conclusion: Our findings suggest that miR-223 provides negative feedback regulation of gouty inflammation development by suppressing production of IL-1b and TNF-a, but not by regulating IL-37 and TGF-b1, and that miR-223 regulates cytokine production by targeting the

more »

... LRP3 inflammasome. These findings provide novel insight into the regulatory role of miR-223 in the spontaneous resolution of acute gouty inflammation. Finally, these results suggest that targeting miR-223 in macrophages might be an effective therapeutic strategy for the treatment of gout flare.