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Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data
2022
Frontiers in Aging
Somatic mutations are DNA variants that occur after the fertilization of zygotes and accumulate during the developmental and aging processes in the human lifespan. Somatic mutations have long been known to cause cancer, and more recently have been implicated in a variety of non-cancer diseases. The patterns of somatic mutations, or mutational signatures, also shed light on the underlying mechanisms of the mutational process. Advances in next-generation sequencing over the decades have enabled
doi:10.3389/fragi.2021.800380
pmid:35822012
pmcid:PMC9261417
fatcat:hsnhvbshibeqvalwrhcbaqvn2m