2-Anilinothiophene als Entkoppler der oxydativen Phosphorylierung in Mitochondrien / 2-Anilinothiophenes, Uncouplers of Oxidative Phosphorylation in Mitochondria

K. H. Büchel, G. Schäfer
1970 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
A series of NH-acidic 2-anilino-3,5-dinitro-thiophenes (II), 2-anilino-3,4-dinitro-5-halo-thiophenes (VI), and some 3,5-dinitro-thienole-derivatives (IX, X) were synthesized. Compounds II and VI are potent uncouplers of oxidative phosphorylation in rat liver mitochondria. The most active comcounds yielded a 50% uncoupling at a concentration of 10-7 ᴍ. With some of the 2-anilino-3,5-dinitro-5-halo-thiophenes (BDCT or DDCT), added to respiring liver mitochondria, a transitory uncoupling of
more » ... ncoupling of energy-linked reactions could be observed which is comparable to the phosphorylating cycles produced by ADP. The mechanism of this effect is discussed
doi:10.1515/znb-1970-1232 fatcat:b7n5auyx3jhl3jwalxe5nr4rhi