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Single nucleotide variant at the alphaVbeta3 integrin associated to Andes virus infection susceptibility
ANDV, agent of hantavirus cardiopulmonary syndrome, enters through integrin cell protein. A change from leucine-to-proline at residues 33 in the PSI-domain (L33P) inhibits ANDV recognition. We assessed the association between this human-variant and ANDV infection. Results We defined susceptible genotype to "TT" (coding leucine) and protective "CC" (coding proline). TT was in 89.2% (66/74) of a first cohort of ANDV-cases and in 60% (63/105) of exposed close-household contacts who remaineddoi:10.1101/502591 fatcat:hhbfr4afzvcphdepi3jnemzfiy