Neurogenesis in Rats After Focal Cerebral Ischemia is Enhanced by Indomethacin

B. D. Hoehn, T. D. Palmer, G. K. Steinberg
2005 Stroke  
and Purpose-Newborn cells may participate in repair following ischemic brain injury, but their survival and function may be influenced by inflammation. Methods-We investigated the effects of indomethacin, a nonsteroidal antiinflammatory drug, on the fate of newborn cells following transient focal ischemia. Results-Bromodeoxyuridine (BrdU)-labeled cells, including migrating neuroblasts, were observed in the neighboring striatum and overlying cortex 1 day poststroke. The density of BrdUϩ cells
more » ... y of BrdUϩ cells labeled with doublecortin, nestin, glial fibrillary acidic protein, or NG2 was increased at 14 and 28 days. Indomethacin increased BrdUϩ cells of all lineages and reduced microglial/monocyte activation. Conclusion-Indomethacin enhanced the accumulation of newborn cells following stroke. (Stroke. 2005;36:2718-2724.)
doi:10.1161/01.str.0000190020.30282.cc pmid:16282546 fatcat:krkuuniaeng37oswtyq3copmkm