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AbstractThe primary factor limiting the success of chemotherapy in cancer treatment is the phenomenon of drug resistance. We have recently introduced a framework for quantifying the effects of induced and non-induced resistance to cancer chemotherapy [8, 7]. In this work, we expound on the details relating to an optimal control problem outlined in . The control structure is precisely characterized as a concatenation of bang-bang and path-constrained arcs via the Pontryagin Maximum Principledoi:10.1101/475533 fatcat:urautfqdsvg7rbge3bq7vi6uza