Siriraj Thai Language Paradigm for Functional MRI: A Pilot Study in Normal Volunteers

Orasa Chawalparit, Sriwimon Manochiopinig, Yudthaphon Vichianin, Jitsupa Wongsripuemtet, Praphun Siwasattayanon, Chanon Ngamsombat, Piya Chavalparit, Panida Charnchaowanish, Prapaporn Pornpunyawuth, Suvicha Chaovongphanit, Yodchanan Wongsawat, Ngamkae Ruangvaravate
Siriraj Med J   unpublished
Objective: To create a language paradigm in Thai for functional MRI (fMRI) study. Methods: Ten normal Thai native speakers with right-handedness from Edinburgh's score underwent fMRI study (BOLD on 3T MR scanner) using created Thai version of language paradigm (SiTP1) with block paradigms of word generation (WG) from Thai letters, verb generation (VG) from nouns, naming pictures (NP), and sentence completion (SC). Individual and group analysis was done using SPM8 to obtain activated areas and
more » ... tivated areas and lateralization index (LI). Results: Participants were 5 males and 5 females (22 to 37 years old). Eight were postgraduate students, one was a residential training fellow and the other one had grade 12 education. In group analysis (whole brain calculation), WG indicated left lateralized (LI = 0.7). The VG and SC paradigm gave ambiguous result (LI = 0.13 and-0.11 respectively), whereas the NP paradigm gave weakly right lateralization (LI =-0.26). For the frontal and parietal lobe, all paradigms gave strong left LI index. Comparison of LI between frontal lobe and parietal, temporal or whole brain from each paradigm were significantly different (p<0.05). For frontal lobe only, no significant difference was found between each paradigm except between VG and NP (p=0.016). Conclusion: There was good lateralization using the created Thai paradigm. Regional calculation from frontal lobe gave the best result. The result supported possibility of using it as an alternative tool to identify the dominant hemisphere in Thai patients.