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Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+in Female Mouse Islets Stimulated by Glucose and Tolbutamide
2014
Endocrinology
Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca 2ϩ concentration ([Ca 2ϩ ] c ) and insulin secretion in mouse islets. Alone PKA activator amplified glucose-and tolbutamide-induced insulin secretion, with a greater impact on second than first phase. Epac activator strongly amplified both phases in response to either
doi:10.1210/en.2014-1247
pmid:24977470
pmcid:PMC4255079
fatcat:d7r7vlyurjev7psas2wepaqqg4