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A bestiary of genetic mouse lines and related tools for inducible and reversible intersectional misexpression
Thanks to the astonishing advances in genetic manipulation, mouse models have become very powerful in their ability to interrogate biological processes. Among functional experiments, misexpression approaches are often modular, such that distinct combinations of driver and effector lines can be used to achieve different effects. However, existing combinations have pitfalls that hinder sophisticated applications like tissue-specific reversible gain-of-function. Here, we put forward an approachdoi:10.1101/754192 fatcat:wj3p7usm25a4lkumlss6htie24