A 64year-old male endoscopic mucosal resection for a colonic adenoma had a follow-up colonoscopy. On colonoscopy, a whitish, slightly elevated lesion, 2 mm in diameter, which had a smooth surface, was found in the descending colon. On histology, proliferation of ganglion cells and nerve fibers within the lamina propria was noted. On immunostaining,the lesion was positive for S-100 protein. The patient had no history of von Recklinghausen' s disease or multiple endocrine neoplasia.

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... occurring only in the colon is very rare. Of note, this patient had the smallest colonic ganglioneuroma reported in the literutune to date.