Delayed maturation of auditory-evoked responses in growth-restricted fetuses revealed by magnetoencephalographic recordings

Isabelle Kiefer, Eric Siegel, Hubert Preissl, Maureen Ware, Burkhard Schauf, Curtis Lowery, Hari Eswaran
2008 American Journal of Obstetrics and Gynecology  
Objective-To investigate fetal brain development of growth-restricted fetuses by using Auditory Evoked Responses (AER) recorded using the non-invasive magnetoencephalographic technique. Methods-Serial fetal recordings starting at 27 weeks of gestation were conducted on a fetal magnetoencephalographic device (fMEG) specially designed for obstetrical assessment. Fifteen normotrophic fetuses were compared to 14 hypotrophic fetuses. After birth, 10 of the hypotrophic fetuses were diagnosed with
more » ... metric growth restriction, four were classified as symmetrically small for gestational age. Results-Fetal AER latencies in both groups showed an average developmental decrease of 12.74 ms/week (p=0.0035). Hypotrophs had longer age-adjusted latencies compared to normotrophs, with a difference of 73.5 ms (p=0.034). The subgroup of symmetrically growth-restricted fetuses showed the longest latencies for age, with a difference from the normotrophs of 120.0 ms (p=0.045). Conclusions- The results indicate that biomagnetically recorded AER can be used to monitor functional brain development in growth-restricted fetuses.
doi:10.1016/j.ajog.2008.04.014 pmid:18533116 pmcid:PMC2954061 fatcat:bibfa7eukbgabjy2vxibyd26tu