Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas [article]

Pascal Grange, Michael Hawrylycz, Partha P. Mitra
2013 arXiv   pre-print
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We apply them to the Allen Atlas of the adult mouse brain, and to the co-expression network of a set of genes related to nicotine addiction retrieved from the NicSNP database. The
more » ... ational methods are implemented in BrainGeneExpressionAnalysis, a Matlab toolbox available for download.
arXiv:1301.1730v1 fatcat:erm3a2c2krgc7f2h4vmugbmonq