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Discriminating between negative cooperativity and ligand binding to independent sites using pre-equilibrium properties of binding curves
2020
PLoS Computational Biology
Negative cooperativity is a phenomenon in which the binding of a first ligand or substrate molecule decreases the rate of subsequent binding. This definition is not exclusive to ligand-receptor binding, it holds whenever two or more molecules undergo two successive binding events. Negative cooperativity turns the binding curve more graded and cannot be distinguished from two independent and different binding events based on equilibrium measurements only. The need of kinetic data for this
doi:10.1371/journal.pcbi.1007929
pmid:32497065
fatcat:3kkmzbzmgjchzaa6vpcigkyxu4