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Reduction of dopamine in basal ganglia and its effects on syllable sequencing in speech: A computer simulation study
2016
Basal Ganglia
Reduction of dopamine in basal ganglia is a common cause of Parkinson's Disease (PD). If dopamine-producing cells die in the substantia nigra, as seen in PD, a typical symptom is freezing of articulatory movements during speech production. Goal: It is the goal of this study to simulate syllable sequencing tasks by computer modelling of the cortico-basal ganglia-thalamus-cortical action selection loop using different levels of dopamine in order to investigate the freezing effect in more detail.
doi:10.1016/j.baga.2015.10.003
fatcat:5ury44sfhvewbgxvv63nwuzvoi