Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex

Motohiro Shiotani, Kyoko Nakano, Emiko Yamauchi, Yoshiya Oda, Satoru Hosokawa, Toyohiko Aoki
2011 Journal of Toxicological Sciences  
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801-and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis
more » ... ycolysis (fructosebisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
doi:10.2131/jts.36.131 pmid:21297352 fatcat:6fbft7gxfnb5plsv762obuvd3q