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Phospholipases A-II (PLA2-II) induces acute pancreatitis through activation of the transcription factor NF-kappaB
2014
European Review for Medical and Pharmacological Sciences
Acute pancreatitis (AP) is an inflammatory disease of the pancreas characterized by local inflammation. Secretory phospholipases A-II (sPLA2-II) have been implicated in triggering AP, but their exact role to evoke AP is largely unknown. NF-kB activation has previously been shown to induce acute pancreatitis. The aim of this study is to explore that PLA2-II triggers AP by activation of NF-kB and the expression of inducible inflammatory mediators. Acute pancreatitis in vivo was induced in Wistar
pmid:24817290
fatcat:i5pbxjinffbytjcdooedaa3zhq