Kinetic resolution of a b-adrenolytic drug with the use of lipases as enantioselective biocatalysts

Adam Sikora, Agata Tarczykowska, Joanna Chałupka, Michał Piotr Marszałł
2018 Medical Research Journal  
Kinetic resolution of a b-adrenolytic drug with the use of lipases as enantioselective biocatalysts AbstrAct The study presented herein is focused on optimisation of the kinetic resolution of racemic propranolol by screening acetylating agent, reaction medium, and enantioselective biocatalysts. The effects of acetylating agent and reaction medium on the efficiency of performed enantioselective biotransformation were investigated. Furthermore, the catalytic activities on nine commercially
more » ... commercially available lipases were tested. Finally, the composition of reaction medium was selected, based on previously obtained results, providing the most efficient process of kinetic resolution of racemic propranolol.
doi:10.5603/mrj.2018.0007 fatcat:3uq2dxikv5be3hmz3qyvfcrtca