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The house officers face multiple challenging situations at work throughout their internship year leading to House Officer Stress Syndrome. Objectives: The paper addresses the aspects of house officer stress syndrome and its influence on their work. Study Design: Cross sectional study. Setting: Tertiary health care setup of Karachi. Period: October to November 2017. Method: A self-designed and self-explanatory questionnaire was prepared and distributed among house officers during work hours.doi:10.29309/tpmj/2019.26.02.3122 fatcat:j2zd4mtqirgwpc3s52i3ihnvxi