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Cranial defects often occur after trauma, neurosurgical procedures like decompressive craniotomy, tumor resections, infection and congenital defects. Because prosthesis production is often costly and requires complex intraoperative processes, this paper reviews clinical data of syndrome of the trephined and its treatment by means of cranioplasty with the application of newer technologies such as virtual surgical planning, computer-aided design, as well as computer-aided manufacturing in orderdoi:10.5281/zenodo.3784357 fatcat:t3awobkvnrfnrlueth7g2p4tgu