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Angiosuppressive and angiostimulatory effects exerted by synthetic partial sequences of endostatin
Clinical Cancer Research
Endostatin, a peptide derived from proteolysis of collagen XVIII, is an endogenous inhibitor of angiogenesis and tumor growth. We have synthesized five peptide fragments designed to cover the whole length of the endostatin molecule (containing 40-50 amino acids each) with the aim of exploring the possibility that a specific sequence within the molecule might be responsible for its antiangiogenic effects. The five peptide sequences, termed fragments I, II, III, IV, and IVox, the latter bearingpmid:14614021 fatcat:gpnfluuxlbhl7nyfgjtc3ctcua