The relationship between personality characteristics and premenstrual syndrome has been considered by the researchers for a long time. The purpose of the present study was to determine the relationship between personality characteristics based on Hexaco six-factor model with symptoms of premenstrual syndrome. Methods: This is a descriptive-analytic study. The statistical population consisted of female students in Kermanshah Medical Sciences University in the academic year 2017-2018. In a random

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... sampling method based on the G-power software 220 ones were selected. The participants responded to Hexaco personality characteristics and premenstrual syndrome questionnaires. The correlation and multivariate regression tests were used for data analysis through SPSS-23 software. There was a significant relationship between personality characteristics of honestyhumility (0.32) and openness experience (0.23) with premenstrual syndrome (p < 0.01). Personality characteristic of honesty-humility (0.37) and agreeableness (−0.14) were predictive of premenstrual syndrome. The results of this study showed that personality factors can be considered as one of the predictors of premenstrual syndrome.