Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism

Tetsuya Marui, Ikuko Funatogawa, Shinko Koishi, Kenji Yamamoto, Hideo Matsumoto, Ohiko Hashimoto, Eiji Nanba, Hisami Nishida, Toshiro Sugiyama, Kiyoto Kasai, Keiichiro Watanabe, Yukiko Kano (+1 others)
2008 International Journal of Neuropsychopharmacology  
Autism is a severe neurodevelopmental disorder of early childhood. Genetic factors play an important role in the aetiology of the disorder. In this study, we considered the NRCAM gene as a candidate gene of autism. This gene is expressed in the central nervous system and located in the 7q region, a susceptibility locus of autism. We conducted a case-control study of 18 single nucleotide polymorphisms (SNPs) within the NRCAM gene for possible association with autism in 170 autistic patients and
more » ... istic patients and 214 normal controls in a Japanese population. Seven SNPs in the NRCAM gene were significantly associated with autism, among which rs2300045 indicated the most prominent result (p=0.
doi:10.1017/s1461145708009127 pmid:18664314 fatcat:vgqnvfkf7ndkhb6gaap5gsfz5m