Hepatocellular Carcinoma (Ordinary Hepatocellular Carcinoma) [chapter]

Arthur Zimmermann
2016 Tumors and Tumor-Like Lesions of the Hepatobiliary Tract  
Chronic liver disease and hepatocellular carcinoma (HCC) can cause a disturbance in the coagulation system. In this study, we aimed to assess the risk factors for venous thromboembolism either acquired or hereditary in patients with HCC. Results: Serum levels of proteins C and S, AT activity, and lipoprotein (a) were significantly lower in both HCC and cirrhotic patients while homocysteine levels were significantly higher in HCC patients. The prevalence of activated protein C resistance (APCR)
more » ... resistance (APCR) and factor V Leiden (FVL) mutation was higher in HCC patients but with no significant differences between the studied groups. With multivariate analysis, prothrombin time, Fbg, protein C and S deficiency, increased lipoprotein (a), hyperhomocysteinemia, APCR, and FVL mutation were independent risk factors for thromboembolic complications in HCC patients. Conclusions: Thrombophilic abnormalities are prevalent in HCC patients, and they have a substantial increased risk of venous thromboembolism. Patients and methods Data were collected from cirrhotic patients with and without HCC, who were admitted to the Hepato-
doi:10.1007/978-3-319-26587-2_2-1 fatcat:gfymmu3anve3tnzfahkb4covmq