The Utility of TEM and AFM Techniques in the Preclinical Assessment of Nanomaterials

J Zheng, D Parmiter, L Graham, K Nagashima, AK Patri, SE McNeil
2010 Microscopy and Microanalysis  
Nanomaterials are showing great promise in their utility for biomedical applications, in areas such as drug delivery, diagnostics and image contrast enhancement. Nanoparticlebased formulations have demonstrated enhanced efficacy and decreased toxicity in comparison to conventional drugs. Comprehensive preclinical characterization of is a critical step in commercialization of nanoparticle-based formulations [1] [2] [3] [4] [5] . Nanoparticle formulations are often comprised of various
more » ... s, including metals, metal oxides, polymers, lipids, biomolecules such as antibodies, proteins and DNA, and other organic compounds. In many cases, the nanoparticle combines two or more of these substances forming a conjugated, encapsulated or core/shell structure. The resulting complexity of nanoparticle-based formulations poses myriad characterization challenges.
doi:10.1017/s1431927610060149 fatcat:lkqw2v5z7rdy3ngxrq6hutiv2i