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2022-RA-809-ESGO Underlying causes and prognosis of mismatch repair deficiency in endometrial cancer other thanMLH1promoter hypermethylation

Merve Kaya, Cathalijne Post, Carli M Tops, Ellen Stelloo, Maartje Nielsen, Melanie E Powell, Alexandra Leary, Linda R Mileshkin, Paul Bessette, Stephanie M de Boer, Ina M Jürgenliemk-Schulz, Ludy Lutgens (+8 others)
2022 Endometrial cancer   unpublished

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the calculated predictive probability values were significantly different between the LNM-positive and -negative groups (P = 1.39 × 10 -10 ), and high diagnostic accuracy of 83.6% area under the curve (AUC) was obtained. The LNM diagnosis requires essentially minimize the time difference between the diagnosis and hysterectomy. Therefore, reverse transcriptionpolymerase chain reaction enabled quantification from RNA in one step within 30 min, for intraoperative diagnosis. Conclusion This
more » ... ic method uses rapid nucleic acid amplification for intraoperative quantification of biomarkers in the primary tissue. Furthermore, the predictive model combined with various clinical variables can be used to discriminate LNM with high accuracy and facilitate individualization of the surgical treatment.
doi:10.1136/ijgc-2022-esgo.244 fatcat:3wa6g2zzpvcd5i7y3jycrgvydy
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Merve Kaya, Cathalijne Post, Carli M Tops, Ellen Stelloo, Maartje Nielsen, Melanie E Powell, Alexandra Leary, Linda R Mileshkin, Paul Bessette, Stephanie M de Boer, Ina M Jürgenliemk-Schulz, Ludy Lutgens, Jan J Jobsen, Elzbieta M van der Steen-Banasik, Remi A Nout, Nanda Horeweg, Tom van Wezel, Vincent Smit, Carien L Creutzberg, Tjalling Bosse. "2022-RA-809-ESGO Underlying causes and prognosis of mismatch repair deficiency in endometrial cancer other thanMLH1promoter hypermethylation." Endometrial cancer (2022)