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This paper proposes an automatic error correction method for melanosome tracking. Melanosomes in intracellular images are currently tracked manually when investigating diseases, and an automatic tracking method is desirable. We detect all melanosome candidates by SIFT with 2 different parameters. Of course, the SIFT also detects non-melanosomes. Therefore, we use the 4-valued difference image (4-VDimage) to eliminate non-melanosome candidates. After tracking melanosome, we re-track thedoi:10.1587/transinf.2013edp7458 fatcat:hdzjexfscjcjli4nuf6payl7zi