Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes

Nobuhide Ogihara, Yuki Usui, Kaoru Aoki, Masayuki Shimizu, Nobuyo Narita, Kazuo Hara, Koichi Nakamura, Norio Ishigaki, Seiji Takanashi, Masanori Okamoto, Hiroyuki Kato, Hisao Haniu (+4 others)
2012 Nanomedicine  
Aims: The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics of base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety of medical fields. Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials. Methods & results: Inflammation reactions in response to the composite were as mild as those of alumina ceramic alone in a subcutaneous
more » ... ntation study. In bone implantation testing, the composite showed good bone tissue compatibility and connected directly to new bone. An in vitro cell attachment test was performed for osteoblasts, chondrocytes, fibroblasts, and smooth muscle cells, and CNT/alumina composite showed cell attachment similar to that of alumina ceramic. Discussion & conclusion: Owing to proven good biocompatibility and bone tissue compatibility, the application of CNT/alumina composites as biomaterials that contact bone, such as prostheses in arthroplasty and devices for bone repair, are expected. 4
doi:10.2217/nnm.12.1 pmid:22401267 fatcat:seqcw7lmvvanzcb5xaca3wnxde