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Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes
Journal of Biological Inorganic Chemistry
Native mass spectrometry is a potent technique to study and characterize biomacromolecules in their native state. Here, we have applied this method to explore the solution chemistry of human carbonic anhydrase I (hCA I) and its interactions with four different inhibitors, namely three sulfonamide inhibitors (AAZ, MZA, SLC-0111) and the dithiocarbamate derivative of morpholine (DTC). Through high-resolution ESI-Q-TOF measurements, the native state of hCA I and the binding of the above inhibitorsdoi:10.1007/s00775-020-01818-8 pmid:32926233 fatcat:cc6eizpetzglxn5wxphmde5jcy