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A Spatially Localized Architecture for Fast and Modular Computation at the Molecular Scale
[article]
2017
bioRxiv
pre-print
Cells use spatial constraints to control and accelerate the flow of information in enzyme cascades and signaling networks. Here we show that spatial organization can be a similarly powerful design principle for overcoming limitations of speed and modularity in engineered molecular circuits. We create logic gates and signal transmission lines by spatially arranging reactive DNA hairpins on a DNA origami. Signal propagation is demonstrated across transmission lines of different lengths and
doi:10.1101/110965
fatcat:uyyswiv3mve3rntdgogafj2pyu