Multiscale Cancer Modeling and In Silico Oncology: Emerging Computational Frontiers in Basic and Translational Cancer Research

Georgios S Stamatakos, Norbert Graf
2013 Journal of Bioengineering and Biomedical Sciences  
Inferring network topologies: involves identification of interaction motifs such as feedback or feed forward loops, methods to infer bistability and robustness, construction and curation of Boolean networks and directed graphs using statistical inference techniques, information theory, and Bayesian analysis [13] . Inferring gene and protein interaction networks: involves applying dimensionality reduction techniques such as principal component analysis, hierarchical clustering and tree
more » ... ons, differential equation based kinetic modeling, rules-based modeling, stochastic and Monte Carlo based modeling of network dynamics [13] .
doi:10.4172/2155-9538.1000e114 pmid:30740263 pmcid:PMC6368085 fatcat:ybzcgmqeajerdbjrq34vp7tg3i