Internet Archive Scholar

Wound healing action of topical nitric oxide releasing poly(acrylic acid)/pluronic F127 hydrogel membranes

LUCAS MILITÃO, MARCELO GANZAROLLI DE OLIVEIRA, MATHILDE CHAMPEAU, CARLOS P. JARA, ELIANA PEREIRA DE ARAUJO
2016 XXIV Congresso de Iniciação Científica da Unicamp   unpublished

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (276.8 kB)
https://web.archive.org/web/20200505170244/https://proceedings.science/proceedings/48/_papers/51722/download/abstract_file1

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL. The file type is application/pdf.

Nitric oxide (NO) plays fundamental roles in wound healing and is endogenously transported by S-nitrosoglutathione (GSNO). In the present work, we incorporated GSNO in hydrogel membranes comprised of poly(acrylic acid)/Pluronic F127 (PAAc/F127/GSNO), with the purpose of delivering NO topically to accelerate wound healing. Chemiluminescence measurements showed that dry PAAc/F127/GSNO membranes undergo slow hydration with concomitant NO release over more than 9 days. Topical application of the
more » ... O/PAAc/F127 membranes in an animal wound healing model led to decreased inflammation and increased collagen deposition and organization in the cicatricial tissue, after 21 days. These results point to a potential medical application of these membranes for accelerating wound healing.
doi:10.19146/pibic-2016-51722 fatcat:kblef7hjujd5rlijubtuoigezu
Citation

LUCAS MILITÃO, MARCELO GANZAROLLI DE OLIVEIRA, MATHILDE CHAMPEAU, CARLOS P. JARA, ELIANA PEREIRA DE ARAUJO. "Wound healing action of topical nitric oxide releasing poly(acrylic acid)/pluronic F127 hydrogel membranes." XXIV Congresso de Iniciação Científica da Unicamp (2016)