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Efficient Bayesian inference of phylogenetic trees from large scale, low-depth genome-wide single-cell data
[article]
2020
bioRxiv
pre-print
A new generation of scalable single cell whole genome sequencing (scWGS) methods, allows unprecedented high resolution measurement of the evolutionary dynamics of cancer cells populations. Phylogenetic reconstruction is central to identifying sub-populations and distinguishing mutational processes. The ability to sequence tens of thousands of single genomes at high resolution per experiment is challenging the assumptions and scalability of existing phylogenetic tree building methods and calls
doi:10.1101/2020.05.06.058180
fatcat:4s6zvqzygrazjol35mobvg7gcu