Three major symptoms of perimenopausal syndrome are vasomotor , psychiatric, and physical symptoms . Whne hot且ashes are most commonly seen . we also often encounter psychiatric symptoms , such as insomnia, anxiety , and depression . We review the combination effect of hormone replacement therapy ( HRT > and antidepressants ( AD )for the treatment of perimenopausal depres − sion ( new 且 y onset depression during the perimenopausal period ) . We conducted a ] iterature search using PubMed , and

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... und numerous articles about the effect of HRT and AD for treatment of hot flashes . However , we found a very sniall number of articles about the effect of HRT and AD for peri − menopausal depression , and most of them were single arm trials of IIRT or AD , We discovered only nine articles of HRT /AD combination therapy . The outcomes were inconsistent , and the effect of HRT /AD combination thcrapy for perimenopausal depression remains unclear . We discussed the