更年期うつ病におけるホルモン療法と抗うつ薬併用の効果 : 文献的検証
Literature review for combination effect of hormone replacement therapy and antidepressants in treatment of perimenopausal depression

Akihiro YAMASHITA, Hiroki SATO, Jun SHIGEMURA, Soichiro NOMURA, Aihide YOSHINO
2013 Journal of Japanese Society of Psychosomatic Obstetrics and Gynecology  
Three major symptoms of perimenopausal syndrome are vasomotor , psychiatric, and physical symptoms . Whne hot且ashes are most commonly seen . we also often encounter psychiatric symptoms , such as insomnia, anxiety , and depression . We review the combination effect of hormone replacement therapy ( HRT > and antidepressants ( AD )for the treatment of perimenopausal depres − sion ( new 且 y onset depression during the perimenopausal period ) . We conducted a ] iterature search using PubMed , and
more » ... und numerous articles about the effect of HRT and AD for treatment of hot flashes . However , we found a very sniall number of articles about the effect of HRT and AD for peri − menopausal depression , and most of them were single arm trials of IIRT or AD , We discovered only nine articles of HRT /AD combination therapy . The outcomes were inconsistent , and the effect of HRT /AD combination thcrapy for perimenopausal depression remains unclear . We discussed the
doi:10.18977/jspog.18.1_125 fatcat:oqlng2bg45hm7d2ma4xyfosixe