Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis

P Carmeliet
1998 Cardiovascular Research  
The development of efficient transgenic technologies in mice has allowed the study of the consequences of genetic alterations on cardiovascular (patho)physiology, although the development of such models have been hampered by size limitation of species resulting in time-consuming, labor-intensive and costly analyses. This overview summarizes the murine models currently available for studying or manipulating angiogenesis, arterial stenosis, atherosclerosis, transplant arteriopathy, thrombosis,
more » ... ombolysis and bleeding and addresses techniques to evaluate vascular development during embryogenesis.
doi:10.1016/s0008-6363(98)00108-4 pmid:9764187 fatcat:oruvtpoe3ncbdiwfe2e6zramsy