Diabetes mellitus (DM) complicated with chronic kidney disease (CKD) has been a severe public health issue in China. This study aimed to investigate the prevalence of adult DM complicated with CKD and its associated factors in Songjiang District, Shanghai. Methods: A large-scale community-based cross-sectional study was conducted among 36,077 participants aged 20-74 years in Songjiang District, Shanghai between June 2016 and December 2017. Epidemiological data of the Shanghai Suburban Adult

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... rt and Biobank (SSACB) and electronic health record (EHR) data based on the big data platform of Songjiang District were combined to estimate the prevalence of adult DM with CKD. Factors associated with DM complicated with CKD were analyzed by using univariate and multivariate logistic regression models with adjusted odds ratios (aOR) and their 95% confidence intervals (CI). Results: The overall prevalence of adult DM with CKD among the community population in Songjiang District, Shanghai was 2.9% (95% CI: 2.8-3.1%). The prevalence significantly increased with age and the prevalence was significantly lower than in men than in women (2.4% vs. 3.3%, P<0.001). Factors were positively associated with adult DM with CKD including female (aOR: 1.40; 95% CI: 1.13-1.72), older age (aOR for 40-59 years age group: 3.85; 95% CI: 1.92-7.72; aOR for ≥60 years age group: 6.17; 95% CI: 3.05-12.47), urban community (aOR: 1.61; 95% CI: 1.38-1.87), HbAlc ≥6.5% (aOR: 24.01; 95% CI: 20.59-28.01), hypertension (aOR: 2.16; 95% CI: 1.77-2.64), dyslipidemia (aOR: 1.58; 95% CI: 1.35-1.84), coronary heart disease (CHD, aOR: 2.15; 95% CI: 1.84-2.52), hyperuricemia (aOR: 1.61; 95% CI: 1.36-1.90) and family history of DM (aOR: 2.73; 95% CI: 2.26-3.29). In sensitivity analysis, those factors except female and urban community were still positively associated with adult DM with CKD. Conclusions: DM with CKD was common among adults in Songjiang District, Shanghai. Effective public health programs should be developed to control DM with CKD for targeted populations.