P-163A PRELIMINARY STUDY ON RETROSPECTIVE EVALUATION OF PULMONARY EMBOLISM RISK ASSESSMENT, THROMBOPROPHYLAXIS AND PULMONARY EMBOLISM INCIDENCE AFTER THORACIC SURGERY

Lei Shen
2017 Interactive Cardiovascular and Thoracic Surgery  
Methods: We retrospectively evaluated 121 lesions in 114 patients with p-Stage IA adenocarcinoma who underwent radical resection after FDG-PET and HRCT. We defined less-invasive lesion as an adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA). We also defined the volume ratio of solid-part to whole tumour as solid tumour ratio (STR). Consolidation to Tumour Ratio (CTR), maximum standardized uptake value (SUVmax), and STR were measured and calculated by using a 3-dimensional
more » ... ing a 3-dimensional image analysis system. The cutoff values were 0.5, 1.0, and 0.125, respectively. Multivariate logistic regression analysis was used to determine the relationship between the 3 radiological parameters and pathological invasiveness. A statistical predictive score was generated from results of multivariate logistic regression. Results: Thirty-four lesions (28.1%) were AIS and MIA. The adjusted odds ratio (95% confidence interval [CI]) was 14.3 (4.9-42.1) for STR (P < 0.001), 5.9 (1.9-18.4) for SUVmax (P=0.002). No significant difference in CTR was observed. The area under the receiver-operating characteristic curve to predict less-invasive lesion was 0.86 (95% CI, 0.78-0.94). In the predictive model with a total score of 3 points was constructed as follows: 1 point for SUVmax of < 1.0; 2 points for STR of < 0.125. The total score predicted less-invasive lesions with an 89.5% probability. Conclusions: The combination of HRCT and FDG-PET in a volumetric analysis programme enabled us to predict less-invasive lesions in patients with earlystage lung adenocarcinoma. Disclosure: No significant relationships.
doi:10.1093/icvts/ivx280.163 fatcat:eszzaa26efeehcbimomumezr7u