In vitro anti-Candida activity and single crystal X-ray structure of ({(1E)-[3-(1H-imidazol-1-yl)-1-phenylpropylidene]amino}oxy)(4-nitrophenyl)methanone

Mohamed I. Attia, Hazem A. Ghabbour, Azza S. Zakaria, Hoong-Kun Fun
2014 Bangladesh Journal of Pharmacology  
Synthesis, characterization, and anti-Candida activity of ({(E)-[3-(1H-imidazol -1-yl)-1-phenylpropylidene]amino}oxy)(4-nitrophenyl)methanone (4) are repor-ted. Compound 4 showed anti-Candida albicans activity (MIC = 0.6862 µmol/mL) being nearly 5-fold more potent than the gold standard antifungal drug, fluconazole (MIC ˃ 3.265 µmol/mL), on the clinical isolates of Candida albicans. Single crystal X-ray structure of the title compound 4 confirmed its assigned (E)-configuration. The compound
more » ... tallizes in the triclinic, P-1 (no. 2), a = 6.4633 (1) Å, b = 11.1063 (2) Å, c = 12.9872 (2) Å, = 67.650 (1)°, = 86.415 (1)°, = 86.776 (1)°, V = 860.01 (3)Å 3 , Z = 2, R(F) = 0.046, wR(F 2 ) = 0.139, T = 296 K. The crystal structure is stabilized by weak intermolecular C-H•••O hydrogen interactions. Article Info
doi:10.3329/bjp.v9i1.16990 fatcat:k7wu2pumxfhddfrshd53dshzt4