GENE VS. LIFE STYLE: A 10-YEAR LONGITUDINAL STUDY DETERMINING MECHANISMS OF INDIVIDUAL DIFFERENCE IN AGE-RELATED ARTERIAL STIFFENING

J. Sugawara, T. Tomoto, N. Noda, S. Matsukura, K. Tsukagoshi, S. Maeda
2018 Japanese journal of physical fitness and sports  
Introduction Increased arterial stiffness is a strong cardiovascular disease (CVD) risk (Vlachopoulos et al. 2010) . Previous cross-sectional and short-term intervention studies suggest large inter-individual differences in magnitude of age-related arterial stiffening as well as efficiency of regular physical activity on arterial destiffening (Iemitsu et al. 2006; Hayashi et al. 2008) . To shed light on underlying mechanisms responsible for individual difference in age-related arterial
more » ... g, we examined contributions of polymorphisms in endothelin (ET) and estrogen-related genes and regular physical activity using a 10-year longitudinal study design.
doi:10.7600/jspfsm.67.81 fatcat:3gt7u3jxvjefjmzdrtnzjkzfzu