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Apoptosis induction by quinazoline-derived alpha1-blockers in prostate cancer cells: biomolecular implications and clinical relevance
European Review for Medical and Pharmacological Sciences
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In patients with androgeri-sensitive prostate cancer androgen-deprivation therapy leads to apoptosis of hormone-dependent cells but it may select out androgen-refractory clones. The apoptosis of prostate cancer cells induced by quinazoline-derived alpha1-adrenoceptor antagonists (doxazosin, terazosin, prazosin) counteracts cell proliferation and may have the potential of reversing or delaying prostate cancer growth. Elucidation of the biomolecular mechanisms whereby
pmid:17405349
fatcat:f7bvxvnjxzd4vgxtchzecmsnza