Bootstrap confidence intervals for dissolution similarity factor f2

Mohammad M Islam
2018 Biometrics & Biostatistics International Journal  
Parametric and non-parametric bootstrap methods are used to investigate the statistical properties of the dissolution similarity factor 2 f . The main objective of this study is to compare the results obtained by these two methods. We estimate characteristics of the sampling distribution of 2 f statistic under these methods with various bootstrap sample sizes using Monte Carlo simulation. A number of bootstrap confidence interval (CI) construction techniques are used to determine a 90 % CI for
more » ... he true value of 2 f under both parametric and non-parametric schemes. The bootstrap sampling distributions of 2 f under both schemes are found to be approximately symmetrical with a non-zero excess of kurtosis. Non-parametric bootstrap confidence intervals for 2 f perform better than those obtained from parametric methods. The Bias corrected (BC) and accelerated bootstrap percentile (BC a ) confidence interval method produce more precise two-sided confidence intervals for 2 f compared to other methods
doi:10.15406/bbij.2018.07.00237 fatcat:olllpakqmjhvte5j2rq4vqyjdy