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To examine the role of the c-Maf transcription factor in the regulation of non-crystallin lens fiber cell specific gene expression. Expression of lens fiber cell genes in c-Maf null mice was analyzed by immunohistochemical and RT-PCR methods. In addition, the effect of c-Maf on fiber cell gene promoter fragments was examined in co-transfection experiments. Examination of protein expression in c-Maf homozygous mutant mice revealed undetectable levels of CP49, CP115 and MIP protein. mRNApmid:12835653 fatcat:xuzoahzizvabdpeasvujdzdvqu