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changed in the small intestine, and the additional injection of exogenous HD-5 improved mortality (p ! 0.05). This study demonstrated the multifunctional roles of the activation process in human defensin and the possibility of using antimicrobial peptides for the treatment of inflammatory bowel diseases in future applications. Abstract Human defensin-5 (HD-5) is one of the major antimicrobial peptides secreted by Paneth cells in the human small intestine. HD-5 is produced and stored as adoi:10.1159/000242114 pmid:20375624 fatcat:jqmefhzruzeublf6lmb27tqg5a