Hydrophilic Photosystem II Inhibitors: Cyanoacrylate Thiolate Salts

John N. Phillips
1990 Zeitschrift für Naturforschung C - A Journal of Biosciences  
Cyanoacrylate thiolate salts such as the sodium salt of ethoxyethyl-3-p-chlorobenzylthio-2-cyano-3-mercapto acrylate have been shown to be relatively slow binding, potent inhibitors of photosynthetic electron transport, that are equally active against thylakoids isolated from atrazine-susceptible and atrazine-resistant Brassica napus seedlings. It has been suggested that their mode of binding involves the substituted benzyl group interacting with the membrane lipids and the thiolate ion
more » ... hiolate ion interacting in the region of the histidine215 residue of the D1 peptide, close to the non-heme Fe centre. This, together with their slow rate of binding, has led to the thiolate salts being classified as phenol type inhibitors.
doi:10.1515/znc-1990-0506 fatcat:ywta72swzrfjpi5dnhciqevvyi