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Autoantibody to ^|^alpha;-Amylase in the Non-obese Diabetic Mouse
The Showa University Journal of Medical Sciences
The non-obese diabetic (NOD) mouse has been developed as an animal model of insulin-dependent diabetes mellitus (IDDM). The islet cell autoantibody and autoantibodies to glutamic acid decarboxylase, heat shock protein, and insulin can be detected and are thought to participate in the autoimmune reaction that leads to IDDM. We found that pancreatic a-amylase decreased after the onset of diabetes and an autoantibody to amylase in the sera of NOD mice could be detected by enzyme-linkeddoi:10.15369/sujms1989.8.1 fatcat:hcgpwekdv5h6xgjpyqna6mfb2u