Test-retest reproducibility of quantitative binding measures of [ 11 C]Ro15-4513, a PET ligand for GABA A receptors containing alpha5 subunits

Colm J. McGinnity, Daniela A. Riaño Barros, Lula Rosso, Mattia Veronese, Gaia Rizzo, Alessandra Bertoldo, Rainer Hinz, Federico E. Turkheimer, Matthias J. Koepp, Alexander Hammers
2017 NeuroImage  
Alteration of γ-aminobutyric acid "A" (GABAA) receptor-mediated neurotransmission has been associated with various neurological and psychiatric disorders. [11C]Ro15-4513 is a PET ligand with high affinity for α5-subunit-containing GABAA receptors, which are highly expressed in limbic regions of the human brain (Sur et al., 1998). We quantified the test-retest reproducibility of measures of [11C]Ro15-4513 binding derived from six different quantification methods (12 variants).
doi:10.1016/j.neuroimage.2016.12.038 pmid:28292717 pmcid:PMC5440177 fatcat:2dmkhunborfibd2cfdewfbtgpu